Ukuzungezisa izikulufu,Kunemindeni emibili yezikulufo ezingamawele, ukukhetha okubalulekile kubalulekile ekuthuthukisweni komkhiqizo oyimpumelelo...
Ukuzungezisa izikulufu kudala ukuxuba okusabalalisa nokuhlakazeka.Ukuxuba kokusabalalisa kukhulisa ukuhlukaniswa nokuhlanganiswa kabusha kwezinto ngenkathi kunciphisa okokufaka kwamandla ngokuxuba nemiphumela ephansi yesandiso kanye ne-planar-shear.Lokhu kuhlanganisa izinto ngendlela efanayo kodwa akunciphisi kakhulu usayizi wezinhlayiyana ezihlakazekile futhi kuveza ukuwohloka okuncane kokushiswa nokugunda kwezinto ezibucayi.
Ukuxutshwa kokuhlakazeka kusebenza izinkambu zokugunda ezinwetshiwe nezihleliwe ukuze kuphulwe izinto ezihlakaziwe zibe kusayizi omncane, ngokufanelekile kusetshenziswa amandla noma ngaphezulu kancane kwezinga lomkhawulo elidingekayo ukuze kuphulwe.
Ukusetshenziswa kwezinto ezihlukene zokuxuba kuvumela i-twin screw extruder ukuthi yenze kokubili ukunciphisa usayizi wezinhlayiyana nokuxuba ukuze ama-API afakwe ku-polymer ngendlela ehlakazekile noma, uma ukunyibilika kwe-API ku-polymer kuphezulu ngokwanele, kufomu elincibilikile.Njengoba i-extrudate iphola ngokushesha lapho iphuma ku-extruder, noma iyiphi i-API encibilika ku-polymer ezingeni lokushisa elixutshwayo ingase ingakwazi ukuphinda icwebe ekupholiseni, okuholela kuzixazululo eziqinile ezigcwele i-supersaturated.Ezimweni ezinjalo ukuzinza komkhiqizo kufanele kulandelwe eduze njengoba ukuvuselelwa kabusha kwe-API ngezilinganiso zesikhathi eside kungenzeka, ikakhulukazi emazingeni okushisa aphakeme esitoreji nokulayishwa okuphezulu kwe-API, futhi kungase kuthinte impilo yeshalofu yomkhiqizo wokugcina.
Kunemindeni emibili yama-twin screw extruder: i-high-speed energy input (HSEI) ama-twin-screw extruder, asetshenziselwa ngokuyinhloko ukuhlanganiswa, ukucubungula okusebenzayo kanye/noma ukuqeda amandla, kanye ne-low-speed late fusion (LSLF) ama-twin-screw extruders, yakhelwe ukuxuba ekusheleni okuphansi kanye nokupompa ngezingcindezi ezifanayo.Izikulufu zingase zijikeleze ngokuhlanganyela (ukuzesula), noma ukuzungezisa ikhawunta (igebe lekhalenda), kanti iningi lama-extruder asetshenziselwa ukuxubana lizungeza ngokuhlanganyela.
Izinhlobo ezihlukene zokufa zisetshenziselwa ukubumba i-extrudate kuphrofayela oyifunayo.Lokhu kufa kufaka phakathi amashidi nefilimu esetshenziswa ekusetshenzisweni kwefilimu ye-transdermal, i-strand dies esetshenziselwa amashubhu ezokwelapha nezinye izinto ezikhipha izidakamizwa, umumo uyafa osetshenziswa ekubumbeni igalelo, kanye ne-co-extrusion dies esetshenziselwa imiklamo yedivayisi yechibi.Izingxenye ezisizayo ezihlukene ezansi nomfula nazo ziyasetshenziswa ekuqedeni, okuhlanganisa okugeza amanzi kanye nemibese yomoya yokupholisa, amabhande okuhambisa ukuhambisa umkhiqizo okhishwe usuka efa kuya ekupheleni komugqa, ama-strand-cutters okusika i-extrudate ibe yishubhu noma izinduku, kanye nama-spoolers okuqoqwa kwe-extrudate.Ama-Pelletizer asetshenziselwa ukusika i-extrudate ibe yizicucu ezincane ukuze kugcwaliswe i-capsule eqondile futhi esimweni samanye amadivaysi okubumba umjovo ukwenza umkhiqizo wokugcina.
Njenganoma yiliphi ifomu lomthamo, ukukhethwa kwempahla kubalulekile ekuthuthukisweni komkhiqizo ophumelelayo.Eziningi zezinhlelo zokusebenza, i-polymer kufanele ibe yi-thermoplastic, izinze emazingeni okushisa asetshenziswe kule nqubo, futhi ihambisane namakhemikhali ne-API ngesikhathi sokukhipha.Kumafomu emithamo yomlomo eqinile, ama-polymers ancibilikayo amanzi ngokuvamile akhethwa phakathi kwama-polymers asevele asetshenziswa emikhiqizweni yezemithi efana ne-poly(ethylene glycol) kanye ne-poly(vinylpyrrolidinone).Ngokukhula kwentshisekelo yokusebenzisa i-HME emikhiqizweni yezemithi, abahlinzeki abakhulu be-polymer nabo sebeqalile ukunikeza ama-polymers aklanyelwe ukusetshenziswa kwemithi.Ngamadivaysi akhipha izidakamizwa, ama-polymers ngokuvamile awancibiliki emanzini, futhi iningi lemikhiqizo esakhiwayo lisebenzisa ama-ethylene vinyl acetate copolymers (EVAs) noma ama-polyurethanes.
I-HME ivumela i-API ukuthi ixutshwe ne-polymer ngaphansi kwengcindezi encane ye-shear kanye ne-thermal futhi ngenxa yalokho ngokwakhiwa kokucekela phansi kwe-API okuhlobene nenqubo.Ama-Antioxidants avame ukufakwa ngaphakathi kokwakhiwa, futhi isikhathi esifushane sokuhlala emgqonyeni (imvamisa ngokulandelana kwamaminithi) kusiza ukunciphisa ukuwohloka kokushisa ikakhulukazi uma kuqhathaniswa nokuxuba inqwaba nezinye izinqubo zokuhlanganisa.
Elinye isu lokulawula i-kinetics elution yezidakamizwa kusuka kumadivayisi afana namaringi angaphakathi esithweni sangasese sowesifazane libandakanya ukunwetshwa kwendlela elula yokukhipha.Ukukhishwa ngesikhathi esisodwa komucu oyinhloko olayishwe izidakamizwa oneshevu ye-polymer elawula ukukhululwa ehlanganisa umongo kunqubo ye-co-extrusion eyodwa kukhiqiza umucu we-core-sheath onezendlalelo ezimbili.Ikhanda le-extrusion eliklanywe ngokukhethekile liphakelwa ama-extruder amabili e-perpendicular - eyodwa ihlinzeka ngokubunjwa okuyisisekelo, enye ihlinzeka ngempahla ye-sheath.I-core-sheath strand iyasikwa futhi iziphetho zixhunywe ukwenza idivayisi yokugcina.
I-HME inikeza abathuthukisi bomkhiqizo bemishini yezokwelapha, ukuncibilikisa amafomu omthamo womlomo namadivayisi akhipha izidakamizwa ngenketho yenqubo eyenza i-API ixube ne-polymer, kuyilapho inciphisa ukucekelwa phansi kwe-API, futhi ivula umnyango wemikhiqizo engakwazi ukulungiswa ngezinye izindlela.
Isikhathi sokuthumela: Aug-01-2017